Harm reduction is a public health philosophy and intervention that seeks to reduce the harms associated with drug use and ineffective drug policies. A basic tenet of harm reduction is that there has never been, and will never be, a drug-free society. The Drug Policy Alliance advocates reducing the harms of drug use through a lens of public health, using accurate, fact-based drug education, drug-related illness and injury prevention, and effective drug treatment for problematic use. We believe that every solution with the potential to promote public health and to mitigate harm should be considered. We continue to seek innovative health approaches to drug use, drug treatment, and drug policy that are based on science and research.